TOX Profile (Toxic Non-Metal Chemicals)

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TOX Profile (Toxic Non-Metal Chemicals)

Toxins are harmful to our health in numerous ways. For example, toxins damage enzymes and impact countless bodily functions. They displace important structural minerals and therefore weaken bones. Toxins damage organs, DNA, as well as cell membranes. And they modify gene expression and impair the body’s ability to detoxify.

This TOX profile screens for the presence of 173 different toxic chemicals including organophosphate pesticides, phthalates, benzene, xylene, vinyl chloride, pyrethroid insecticides, acrylamide, perchlorate, diphenyl phosphate, ethylene oxide, acrylonitrile, and more. This profile also includes Tiglylglycine (TG), a marker for mitochondrial disorders resulting from mutations of mitochondrial DNA. These mutations can be caused by exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies.

Why this test is important:

Every day, we are exposed to hundreds of toxic chemicals through products like pharmaceuticals, pesticides, packaged foods, household products, and environmental pollution. As we have become more exposed to chemical-laden products and to toxic chemicals in food, air, and water, we have been confronted with an accelerating rate of chronic illnesses like cancer, heart disease, chronic fatigue syndrome, chemical sensitivity, autism spectrum disorders, ADD/AD(H)D, autoimmune disorders, Parkinson’s disease, and Alzheimer’s disease.

This test measures the following pollutant metabolites:

2-Methylhippuric Acid (2MHA), 3-Methylhippuric Acid (3MHA), 4-Methylhippuric Acid (4MHA)
These are metabolites of xylenes, solvents found in paints, lacquers, cleaning agents, pesticides, and gasoline. Exposure to xylenes generates methylhippuric acid isomers.

N-acetyl phenyl cysteine (NAP)
NAP is a metabolite of benzene. Benzene is a solvent that is widespread in the environment. It is found in cigarette smoke and gasoline, and is a byproduct of all types of combustion, including motor vehicle exhaust.

Phenylglyoxylic Acid (PGO)
Exposure to environmental styrene may slightly increase phenylglyoxylic and mandelic acid. Reduce exposure by eliminating the use of plastic and styrofoam containers for cooking, reheating, eating or drinking.

2-Hydroxyisobutyric Acid (2HIB)
2-Hydroxyisobutyric acid is formed endogenously as a product of branched-chain amino acid degradation and ketogenesis. This compound is also the major metabolite of gasoline octane enhancers such as MTBE and ETBE. Elevated levels indicate environmental exposure and very high values have been reported in genetic disorders.

Monoethyl Phthalate (MEP)
MEP from diethyl phthalate is the most abundant phthalate metabolite found in urine. Diethyl phthalate is used in plastic products. Elevated values indicate exposure from various possible sources.

Dimethylphosphate (DMP) & Diethylphosphate (DEP)
DMP and DEP are major metabolites of many organophosphate pesticides. Reduce exposure by eating organic foods and avoiding use of pesticides in your home or garden. Living near agricultural areas or golf courses and areas regularly sprayed with pesticides will increase exposure.

3-Phenoxybenzoic Acid (3PBA)
3-Phenoxybenzoic acid is a metabolite of pyrethroid insecticides.

2,4-Dichlorophenoxyacetic Acid (2,4-D)
2,4-D was an ingredient in Agent Orange, and is most commonly used in agriculture of genetically modified foods, and as a weed killer for lawns.

Tiglylglycine (TG)
TG is a marker for mitochondrial dysfunction. Mutations of mitochondria DNA may result from exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies.

N-acetyl-S-(2-carbamoylethyl)-cysteine
NAE is a metabolite of acrylamide, which is detoxified through a two-step process. First acrylamide is metabolized by the cytochrome P450s. Second it is conjugated to glutathione in order to make it more water soluble. Acrylamide is used in many industrial processes such as plastics, food packaging, cosmetics, nail polish, dyes, and treatment of drinking water. High levels of acrylamide can elevate a patient’s risk of cancer and cause neurological damage.

Diphenyl Phosphate
This is a metabolite of the organophosphate flame retardant triphenyl phosphate (TPHP), which is used in plastics, electronic equipment, nail polish, and resins. TPHP can cause endocrine disruption. Studies have also linked TPHP to reproductive and developmental problems.

Perchlorate
Perchlorate is used in the production of rocket fuel, missiles, fireworks, flares, explosives, fertilizers, and bleach. Studies show that perchlorate is often found to contaminate water supplies and food sources. It can disrupt the thyroid’s ability to produce hormones. The EPA has also labeled perchlorate a likely human carcinogen.

N-Acetyl (3,4-Dihydroxybutyl) Cysteine (NABD)
NADB is a metabolite of 1,3 butadiene, which is evident of exposure to synthetic rubber such as tires. 1,3 butadiene is a known carcinogen and has been linked to increased risk of cardiovascular disease. Individuals that come into contact with rubber, such as car tires, could absorb 1,3 butadiene through the skin.

N-Acetyl (2,Hydroxypropl) Cysteine (NAHP)
NAHP is a metabolite of propylene oxide which is used in the production of plastics and as a fumigant. It is also used in the preparation of lubricants, surfactants, and oil demulsifiers and as a food additive, an herbicide, a microbicide, an insecticide, a fungicide, and a miticide. Propylene oxide is a probable human carcinogen.

N-Acetyl (Propyl) Cysteine (NAPR)
NAPR is a metabolite of 1-bromopropane. Chronic exposure can lead to decreased cognitive function and impairment of the central nervous system. Acute exposure can lead to headaches.

2-Hydroxyethyl Mercapturic Acid (HEMA)
HEMA is a metabolite of ethylene oxide, which is used in the production of agrochemicals, detergents, pharmaceuticals, and personal care products. Chronic exposure to ethylene oxide has been determined to be mutagenic to humans. HEMA is also a metabolite of vinyl chloride and halopropane, which are used in many commercial chemical processes such as foam glueing, dry cleaning, and in the production of solvents.

N-Acetyl (2-Cyanoethyl) Cysteine (NACE)
NACE is a metabolite of acrylonitrile, which is used in the production of acrylic fibers, resins, and rubber. Acrylonitrile is metabolized by the cytochrome P450s and then conjugated to glutathione. Supplementation with glutathione should assist in the detoxification of acrylonitrile.

N-acetyl-S-(3-hydroxypropyl)-L-cysteine (3-HPMA)
3-HPMA is a metabolite of acrolein. Acrolein is commonly used as an herbicide to control weeds and algae in irrigation canals. Humans are exposed to acrolein via oral (fried foods, alcoholic beverages, and water), respiratory (cigarette smoke and automobile exhaust), and dermal routes. On the cellular level, acrolein exposure has diverse toxic effects, including DNA and protein adduction, oxidative stress, mitochondrial disruption, membrane damage, and immune dysfunction.

Test Type:

This test is done at-home via urine sample collected first thing in the morning, ideally prior to eating or drinking anything. Detailed instructions will be included inside your test kit.

Please note:

All tests are authorized and reviewed by a physician from our partner laboratory.

Sample Test Report

Results:

In approximately 14 business days, DHA Laboratory will email you your test results. For a detailed interpretation of your results as well as recommendations for next steps, please schedule a consultation with a Village Green nutritionist.

Questions?

Email a Village Green nutritionist or call 800-869-9159.